Автор: Randall J. Mrsny and Ann Daugherty
Название: Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes
Издательство: CRC Press
Год: 2010
ISBN: 9781420078060; 1420078062
Серия: Drugs and the Pharmaceutical Sciences (Book 202)
Язык: English
Формат: pdf
Размер: 12,4 mb
Страниц: 288

The promise of biotechnology and an increased understanding of the human genome have resulted in an explosion of protein and peptide therapeutics entering research and development pipelines in biopharmaceutical as well as traditional pharmaceutical companies. Increasingly, these protein and peptide candidates are being designed to address previously unbeatable diseases and conditions. To advance these molecules into clinical trials, however, an understanding of their pharmacokinetic, pharmacodynamic, and metabolic fate is required. The study of these events represents emerging disciplines with issues and challenges distinct from those of small molecules, on which many of the principles of these fields were initially developed.

Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.