Автор: Harry G. Brittain
Название: Polymorphism in Pharmaceutical Solids, 2nd Edition
Издательство: CRC Press
Год: 2009
ISBN: 9781420073218; 1420073214
Серия: Drugs and the Pharmaceutical Sciences (Book 192)
Язык: English
Формат: pdf
Размер: 10,9 mb
Страниц: 656

The content of the present edition of Polymorphism in Pharmaceutical Solids has expanded to reflect the larger scope of topics having interest to development scientists. The book is now divided into six main sections, the first dealing with thermodynamic and theoretical issues. Within this initial section, one will find updated chapters from the first edition, "Theory and Principles of Polymorphic Systems" and "Application of the Phase Rule to the Characterization of Polymorphic and Solvatomorphic Systems." Reflecting the growing trend in predictive science, a new chapter entitled "Computational Methodologies: Toward Crystal Structure and Polymorph Prediction" is now featured in this section.

The second section of the new edition features preparative methods for polymorphs and solvatomorphs, and the single chapter of the first edition has been split into two chapters entitled "Classical Methods of Preparation of Polymorphs and Alternative Solid Forms" and "Approaches to High-Throughput Physical Form Screening and Discovery." In the next section, one will find chapters relating to the structural properties of polymorphs and solvatomorphs, updating the chapters from the first edition, "Structural Aspects of Polymorphism" and "Structural Aspects of Solvatomorphic Systems." With greater interest developing about the advantageous properties of co-crystal systems, it was appropriate to expand the structural section to include a new chapter entitled "Pharmaceutical Co-crystals: A New Opportunity in Pharmaceutical Science for a Long-Known but Little-Studied Class of Compounds."