Автор: A. Rodrigues David
Название: Drug-Drug Interactions, 2nd Edition
Издательство: CRC Press
Год: 2008
ISBN: 978-0849375934
Серия: Drugs and the Pharmaceutical Sciences (Book 179)
Язык: English
Формат: pdf
Размер: 15,1 mb
Страниц: 768

All effective drugs have the potential for producing both benefits and risks associated with desired and undesired effects. The particular response to a drug by a patient is driven in one way or another by the concentration of that drug, and sometimes its metabolites, at the effect sites within the body. Accordingly, it is useful to partition the relationship between drug administration and response into two phases, a pharmacokinetic phase, which relates drug administration to concentrations within the body produced over time, and a pharmacodynamic phase, which relates response (desired and undesired) produced to concentration. In so doing, we can better understand why patients vary in their response to drugs, which includes genetics, age, disease, and the presence of other drugs.

This book is providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.