Название: An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks
Автор: Karthik Raman
Издательство: Chapman and Hall/CRC
Год: 2021
Страниц: 359
Язык: английский
Формат: pdf (true)
Размер: 25.7 MB

This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks - a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields.

This book is divided into four parts. Following a short introduction to modelling, Part I focusses on static networks, studied using graph-theoretic approaches. Part II moves on to dynamic modelling, covering classic ODE modelling, parameter estimation, and also Boolean networks. Part III is devoted to constraint-based modelling of metabolic networks, including methods to study perturbations. Part IV focusses on advanced topics such as the modelling of interactions between microbes in microbiomes, or between pathogens and their hosts, an introduction to synthetic biology and the design of biological circuits, and, lastly, a discussion on robustness and evolvability that pervade biological systems.

Pre-requisites:
The only pre-requisite for this text is a familiarity with a high-level programming language aside from an intellectual curiosity towards how mathematical and computational approaches aid in understanding biology. An engineering mathematics background will be advantageous but not strictly necessary.

Key Features:

- A hands-on approach to modelling
- Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models
- Thoughtful exercises to test and enable understanding of concepts
- State-of-the-art chapters on exciting new developments, like community modelling and biological circuit design
- Emphasis on coding and software tools for systems biology
- Companion website featuring lecture videos, figure slides, codes, supplementary exercises, further reading, and appendices:https://ramanlab.github.io/SysBioBook/

An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks is highly multi-disciplinary and will appeal to biologists, engineers, computer scientists, mathematicians and others.